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Cayman Chemical ANTIBODY PK68 5mg
Supplier: Cayman Chemical 366535 MG
A RIPK1 inhibitor (IC50 = 90 nM); selective for RIPK1 over RIPK3 and a panel of 369 kinases at 1,000 nM; inhibits necroptosis induced by TNF-α, a Smac mimetic, and z-VAD in HT-29 colon cancer cells (EC50 = 23 nM); reduces the number of lung metastases in a B16/F10 murine melanoma model at 5 mg/kg; increases survival and prevents decreases in body temperature and increases in serum Il-1β levels in a mouse model of Tnf-α-induced SIRS at 1 mg/kg
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