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Cayman Chemical ANTIBODY PQR530 25mg
Supplier: Cayman Chemical 2856325 MG
A dual inhibitor of PI3Kα and mTOR (IC50s = 11.1 and 7.4 nM, respectively); inhibits phosphorylation of Akt and ribosomal S6 kinase in A2058 melanoma cells (IC50s = 62.2 and 61.1 nM, respectively); inhibits cell growth in a panel of 66 cancer cell lines (mean GI50 = 0.43 µM); reduces tumor growth in an OVCAR-3 mouse xenograft model at 25 mg/kg; decreases the number of seizures per week in a Tsc1GFAP conditional knockout mouse model of epilepsy
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