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Cayman Chemical ANTIBODY PYR41 5mg
Supplier: Cayman Chemical 152265 MG
An irreversible inhibitor of ubiquitin-activating enzyme (E1; IC50 = 50 = 6.4 µM); selective for E1 over E2 but does inhibit autoubiquitination of the HECT domain E3 Nedd4 at 50 µM; inhibits proteasome-dependent and -independent ubiquitination and protein degradation at 50 µM; preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells at 1-20 µM; also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl
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