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Cayman Chemical ANTIBODY Ro 67-7476 1mg
Supplier: Cayman Chemical 119931 MG
A positive allosteric modulator of mGluR1; enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM); selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at 10 μM; increases the amplitude of mGluR1 EPSCs evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices; activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM)
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