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Cayman Chemical ANTIBODY SenIcapoc 500mg
Supplier: Cayman Chemical 29679500 MG
An inhibitor of IKCa1/KCa3.1 channels; inhibits A23187-induced rubidium efflux from and dehydration of isolated human RBCs (IC50s = 11 and 30 nM, respectively); reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease at 10 mg/kg twice per day; inhibits production of IL-2, IFN-γ, IL-12, and IL-17A in PMA- and ionomycin-stimulated CD3+ T cells at 1 μM; increases the paw withdrawal threshold in a rat model of CCI of the sciatic nerve at 100 mg/kg
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