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Cayman Chemical ANTIBODY SN-38 50mg
Supplier: Cayman Chemical 1563250 MG
An inhibitor of topoisomerase I and an active metabolite of irinotecan; induces topoisomerase I-dependent DNA cleavage in a cell-free assay at 0.1, 1, and 10 µM; induces DNA single-strand breaks in HT-29 cells at 200 nM; induces cytotoxicity in HT-29 cells (IC50 = 8.8 nM); reduces tumor volume without affecting body weight in an MX-1 breast cancer mouse xenograft model at 100 mg/kg per day
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