Cayman Chemical ANTIBODY TAK-063 50mg

Supplier:  Cayman Chemical 2220850 MG

A potent inhibitor of PDE10A (IC50 = 0.3 nM); >15,000-fold selective for PDE10A over other PDEs and exhibits <50% inhibition at 91 receptors, ion channels, and enzymes at a concentration of 10 μM; increases cAMP and cGMP levels by 1.3- and 2.14-fold, respectively, in the striatum of mice when administered at a dose of 0.3 mg/kg; reverses PCP-induced hyperlocomotion (MED = 0.3 mg/kg, p.o.) in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg; reverses (+)-MK-801-induced hyperlocomotion (MED = 0.1 mg/kg, p.o.) but has no effect on plasma prolactin or glucose levels in rats

Catalog No. 50-298-5709