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Cayman Chemical ANTIBODY TAK-385 25mg
Supplier: Cayman Chemical 2951225 MG
A GnRHR antagonist (IC50s = 0.33 and 0.32 nM for the human and monkey receptors, respectively); selective for these receptors over the rat GnRHR receptor (IC50 = 9,800 nM), as well as a panel of 134 enzymes and receptors at 10 µM; 95-fold more potent at inhibiting GnRH-induced arachidonic acid release in CHO cells expressing human GnRHR compared with those expressing monkey GnRHR; decreases testis, ventral prostate, ovary, and uterus weight in human GNRHR knock-in mice at 3-200 mg/kg per day for 28 days; decreases plasma luteinizing hormone levels in castrated cynomolgus monkeys at 1 and 3 mg/kg
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