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Cayman Chemical ANTIBODY TAK-779 1mg
Supplier: Cayman Chemical 267441 MG
An antagonist of CCR5, CCR2b, and CXCR3; inhibits CCR5 and CXCR3 (IC50s = 236 and 369 nM, respectively) and CCR5 and CCR2b (IC50s = 1.4 and 27 nM, respectively); inhibits the replication of clinical isolates of R5, but not X4, HIV-1 in human PBMCs (EC50s = 1.6-3.5 and >20,000 nM, respectively); inhibits ovalbumin-induced increases in CCR5, CXCR3, IFN-γ, and TNF-α expression in mouse lung, as well as the number of total cells, lymphocytes, and eosinophils in BALF, in a mouse model of asthma at 250 mg per animal per day; increases intestinal allograft survival in a rat model of small intestine transplantation at 10 mg/kg per day
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