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Cayman Chemical ANTIBODY TAS 0728 25mg
Supplier: Cayman Chemical 3352825 MG
A covalent HER2 inhibitor (IC50 = 36 nM); selective for HER2 over panels of 386 and 374 additional kinases, as well as a panel of 68 non-kinase enzymes, at 1 µM; inhibits HER2 autophosphorylation in HER2-overexpressing SK-BR-3 cells; inhibits the growth of six HER2-amplified cancer cell lines (GI50s = 1.6-31 nM); reduces tumor volume in NCI N87 and BT474 mouse xenograft models
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