Cayman Chemical ANTIBODY TCS 21311 25mg

Supplier:  Cayman Chemical 3006325 MG

A JAK3 inhibitor (IC50 = 8 nM); selective for JAK3 over JAK1, JAK2, and TYK2 (IC50s = 1,017, 2,550, and 8,055 nM, respectively) but does inhibit GSK-3β, PKCα, and PKCθ (IC50s = 13, 68, and 3 nM, respectively); inhibits cytokine-induced STAT5 phosphorylation in CTLL and M-07 cells (IC50s = 1,294 and 525 nM, respectively) and TCR/CD28-mediated T cell activation in Jurkat cells (IC50 = 689 nM); increases proliferation of mouse embryonic NPCs and human iPSC-derived NPCs in the absence of BMP7 at 0.3 µM

Catalog No. 50-299-0513