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Cayman Chemical ANTIBODY SGA360 5mg
Supplier: Cayman Chemical 219865 MG
A selective modulator of AhR; competitively binds AhR (IC50 = 3 µM); represses IL-1β-induced SAA1 gene expression in Huh7 cells; reduces inflammation and decreases the mRNA expression of COX-2, IL-6, IL-1β, SAA3, and IL-10 in wild-type, but not AhR knockout, mice in a model of inflammatory EAr edema; reduces acute inflammation in murine models of septic shock, gout, and peritonitis when the high-affinity AhR variant is expressed
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