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Cayman Chemical ANTIBODY TropIfexor 5mg
SDP

Supplier:  Cayman Chemical 257485 MG

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An FXR agonist; enhances the interaction between the human FXR ligand binding domain and the SRC-1 peptide in an HTRF coactivator interaction assay (EC50 = 0.2 nM); increases expression of the FXR target genes BSEP and SHP and decreases expression of CPY8B1 in rat liver in a dose-dependent manner, as well as increases expression of SHP and FGF15 in rat ileum; reduces triglyceride levels by 79% in rat serum at 0.3 mg/kg; reduces fibrosis, inflammation, and steatosis in a mouse model of NASH

Catalog No. 50-293-6308


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