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Cayman Chemical ANTIBODY V-9302 25mg

Supplier: Cayman Chemical 2768825 MG
An inhibitor of ASCT2; inhibits glutamine uptake (IC50s = 9 and 9.6 µM for the rat and human transporters, respectively); reduces cell viability of a variety of cancer cell lines, including HCT116, HT-29, COLO 205, and RKO cells (EC50s = 8.9, 9.4, 14.5, and 8.3 µM, respectively); reduces glutamine uptake into tumor tissue and prevents tumor growth in HCT116 and HT-29 mouse xenograft models expressing K-RasG13D and BRAFV600E mutations, respectively, at 75 mg/kg per day for 21 days
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