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Cayman Chemical ANTIBODY VU0360223 5mg
Supplier: Cayman Chemical 119955 MG
A selective, negative allosteric modulator of the mGlu5 (IC50 = 61 nM; Ki = 477 nM); 10 μM results in a near complete blockade of the glutamate response in cortical astrocytes; 30 mg/kg in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction
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