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Cayman Chemical ANTIBODY VU0661013 1mg

Supplier: Cayman Chemical 395241 MG
An Mcl-1 inhibitor (Ki = 97 pM); selective for Mcl-1 over Bcl-xL and Bcl-2 (Kis = >40 and 0.73 µM, respectively); inhibits cell growth in a panel of AML cell lines (GI50s = 0.16-7.62 µM); decreases blood, bone marrow and spleen leukemic burden, reduces splenomegaly, and increases survival in a MV4-11 disseminated AML mouse xenograft model at 75 mg/kg; selectively inhibits GPX4 (IC50 = 8.4 µM) over GPX1, GPX2, GR, and TrxR1
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