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Cayman Chemical ANTIBODY WAY-181187 10mg
Supplier: Cayman Chemical 2346110 MG
A 5-HT6 receptor agonist; increases intracellular cAMP levels in HeLa cells expressing 5-HT6 (EC50 = 6.5 nM); selectively binds to 5-HT6 over 5-HT2B, 5-HT2C, and 5-HT7 (Kis = 2,458, 124, and 679 nM, respectively); selective for 5-HT6 over a panel of 31 receptors and ion channels at 100 nM; increases extracellular GABA levels in the rat frontal cortex at 10 mg/kg; reduces schedule-induced polydipsia, an adjunctive model of compulsive disorder, in rats at 178 mg/kg; has antidepressant-like activity in rats at 17 mg/kg and anxiolytic-like activity in rats at 10 and 17 mg/kg
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