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Cayman Chemical ANTIBODY WAY-600 10mg
Supplier: Cayman Chemical 2921410 MG
An mTOR inhibitor (IC50 = 0.009 µM); selectively inhibits mTOR over PI3Kα and PI3Kɣ (IC50s = 1.96 and 8.45 µM, respectively) and 24 additional lipid and protein kinases in a panel (IC50s = >50 µM for all); decreases phosphorylation of Akt and S6K1 in a cell-free assay at 0.2, 1, and 5 µM; decreases proliferation of nine cancer cell lines, including breast, prostate, glioma, kidney, and colorectal cancer cells (IC50s = 0.6-2.5 µM); reduces tumor growth in a HepG2 mouse xenograft model at 10 mg/kg for 14 days
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