Cayman Chemical ANTIBODY Z-FF-FMK 10mg

Supplier:  Cayman Chemical 4102610 MG

A PI3Ka inhibitor (Ki 0.034 nM) selective for PI3Ka over PI3KB PI3K and PI3KY (Kis 99.7 12.2 and 18.2 nM respectively) and is 4.4-fold selective in decreasing the phosphorylated levels of PRAS40 in HCC1954 cells which express wild-type p110a and p110aH1047R over HDQ-P1 cells which only express wild-type p110a induces PARP cleavage a marker of apoptosis in HCC1954 cells at 111 nM reduces the levels of phosphorylated Akt and PRAS40 and the levels of mutant p110a in HCC1954 cells but not HDQ-P1 cells at 111 333 and 1000 nM decreases tumor volume in an HCC1954 mouse xenograft model at 25 or 50 mg/kg per day

Catalog No. 50-294-3317