ABclonal Technology AP0373-500ul Phospho-JAK2-Y100

Supplier:  ABclonal Technology AP0373500UL

This gene encodes a non-receptor tyrosine kinase involved in cytokine and growth factor signaling The primary isoform contains a FERM domain for erythropoietin receptor association an SH2 domain for STAT binding a pseudokinase domain and a C-terminal kinase domain Cytokine binding triggers autophosphorylation and activation of this kinase which then phosphorylates STAT proteins Growth factors like TGF-beta 1 also activate this kinase leading to STAT translocation to the nucleus to influence gene transcription Mutations in this gene are linked to inflammatory diseases and cancers It is a target of IL6 which regulates immune responses and inflammation Disruption of the IL6/JAK2/STAT3 pathway causes increased cell proliferation and myeloproliferative neoplasms A mutation in the pseudokinase domain causes constitutive activation making it hypersensitive to cytokine signaling Alternative splicing produces multiple isoforms

Catalog No. 50-001-13503