ABclonal Technology Phospho-JAK2-Y1007/1008 Rabbit pAb

Supplier:  ABclonal Technology AP0531500UL

This gene encodes a non-receptor tyrosine kinase involved in cytokine and growth factor signaling. The primary isoform contains a FERM domain for receptor association, an SH2 domain for STAT binding, a pseudokinase domain, and a C-terminal kinase domain. Cytokine binding activates the kinase, which then phosphorylates and activates STAT proteins. Growth factors like TGF-beta 1 also activate this kinase, influencing gene transcription. Mutations in this gene are linked to inflammatory diseases and cancers. It is a target of IL6, involved in immune response and inflammation. Disruption of the IL6/JAK2/STAT3 pathway leads to increased cellular proliferation and myeloproliferative neoplasms. A mutation in the pseudokinase domain causes constitutive activation, leading to hypersensitivity to cytokines. This gene and its pathway are therapeutic targets for inflammatory conditions. Alternative splicing produces multiple isoforms.

Catalog No. 50-001-10315