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ABclonal Technology Pan Phospho-Serine/Threonine Rabbit pAb
Supplier: ABclonal Technology AP08931000UL
Phosphorylation, a key post-translational modification, regulates protein function by adding a phosphoryl group from ATP to serine (~86%), threonine (~12%), or tyrosine (~2%), with removal by phosphatases. It can occur at other amino acids as well and affects protein structure, function, and interactions. Phosphorylation is essential for numerous cellular processes such as signal transduction, cell cycle regulation, differentiation, metabolism, motility, and apoptosis. Different phosphorylation sites can lead to distinct outcomes. For example, phosphorylation of RAF1 at specific serine or threonine residues activates it in the MAPK pathway, while phosphorylation at other sites inhibits its activity.
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