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ABclonal Technology Phospho-PPP1R12A/PPP1R12B/PPP1R12C-T696 Rabbit pAb
Supplier: ABclonal Technology AP1164500UL
Myosin phosphatase target subunit 1 (MBS) is a subunit of myosin phosphatase, which regulates actin-myosin interactions via Rho, a small GTPase. RhoA, in its GTP-bound form, interacts with MBS to control myosin light chain (MLC) phosphorylation, affecting smooth muscle contraction and nonmuscle cell function. Rho-kinase, activated by GTP-RhoA, phosphorylates MBS, inhibiting myosin phosphatase. Overexpression or activation of RhoA increases MBS and MLC phosphorylation. MBS plays a critical role in modulating actin-myosin interactions and is regulated by RhoA signaling. Several isoforms of this gene arise from alternative splicing.
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