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Cayman Chemical AP1189acetate 10mg
Supplier: Cayman Chemical 3740010 MG
A biased MC1R and MC3R agonist; induces ERK1 and ERK2 phosphorylation but not canonical cAMP production in HEK293 cells expressing human MC1R or MC3R from 10 pM to 1 mM; reduces zymosan-induced IL-1β, IL-6, and TNF-α production in primary peritoneal macrophages isolated from wild-type but not Mc3r-/- mice from 0.1-10 nM; reduces zymosan-induced TNF-α production in primary macrophages isolated from Mc1r-/- mice; promotes efferocytosis in primary mouse macrophages; reduces peritoneal neutrophil infiltration in a mouse model of zymosan-induced acute peritonitis at 1, 3, and 10 mg/kg; reduces paw volume, the number of paws affected, and disease severity in a mouse model of arthritogenic serum-induced arthritis at 50 mg/kg
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