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Medchemexpress LLC Apcin-A | 1683617-62-0 | 98.0% | 1 ML
Supplier: Medchemexpress LLC HY13084110MM/1ML
Apcin-A is a small molecule inhibitor that selectively targets the cell division cycle protein Cdc20, a derivative of Apcin. It competitively binds to the D-box binding pocket of Cdc20, inhibiting substrate ubiquitination mediated by the anaphase promoting complex APC/C-Cdc20. This action prevents Cdc20 from binding to substrates like securin and cyclin B1, hindering anaphase initiation and cell cycle exit.
- Selectively targets cell division cycle protein Cdc20.
- Inhibits substrate ubiquitination mediated by APC/C-Cdc20.
- Prevents Cdc20 binding to securin and cyclin B1.
- Hindrance of anaphase initiation and cell cycle exit.
- Potential for anti-mitotic drug development.
- Potential to overcome tumor chemotherapy resistance.
- Can be used in PROTAC synthesis.
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