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Selleck Chemical LLC Apitolisib (GDC-0980) S2696-1g
Supplier: Selleck Chemical LLC S26961G
Apitolisib (GDC-0980 RG7422 GNE 390) is a potent class I PI3K inhibitor for PI3K / / / with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays respectively Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay and highly selective versus other PIKK family kinases Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells Phase 2
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