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Medchemexpress LLC Aprinocarsen sodium | 331257-53-5 | 98.4% | 6435.2 (free acid) | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1484131MG

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Aprinocarsen sodium (ISIS 3521) is a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). This 20-mer oligonucleotide regulates cell differentiation and proliferation, showing potential as a chemotherapeutic compound for human cancers by inhibiting the growth of tumor cell lines in nude mice.

  • Specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α).
  • Regulates cell differentiation and proliferation.
  • Inhibits growth of human tumor cell lines in nude mice.
  • Dose-dependently inhibits PKC-alpha in human bladder carcinoma (T-24) cells.
  • Shows an IC50 value of 50-100 nM for PKC-α mRNA reduction.
  • Well-tolerated in in vivo studies with no apparent acute toxicity.

Catalog No. 50-003-60171


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