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Apexbio Technology LLC APY29 1216665-49-4 25mg
Supplier: Apexbio Technology LLC B328825
APY29 (CAS 1216665-49-4) is an allosteric modulator of the endoplasmic reticulum (ER) transmembrane protein IRE1 exhibiting an IC50 of 0 28 M for IRE1 activation APY29 interacts with the ATP-binding site of wild-type IRE1 promoting kinase domain activation even in the absence of upstream ER stress signals By stabilizing a distinct conformation of the kinase domain APY29 partially restores IRE1 s RNase activity achieving approximately 60% of normal splicing of XBP1 substrate in dephosphorylated states This compound also increases the oligomer/monomer ratio of IRE1 ultimately reducing its trans-autophosphorylation APY29 is a valuable tool for investigating IRE1 signaling and ER stress pathways in cellular models
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