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Apexbio Technology LLC AR-42 (OSU-HDAC42) 935881-37-1 10mg
Supplier: Apexbio Technology LLC A410410
AR-42 (OSU-HDAC42 CAS 935881-37-1) is a hydroxamate-derived small molecule structurally based on phenylbutyrate functioning as a potent histone deacetylase (HDAC) inhibitor It modulates chromatin structure by inhibiting HDAC activity (IC50 16 nM) thus increasing histone H3 acetylation -tubulin acetylation and expression of p21 markers indicative of HDAC inhibition AR-42 also affects apoptotic and survival pathway regulators including Akt Bcl-xL Bax Ku70 and Survivin and likely acts partially through suppression of the PI3K/Akt signaling axis It shows antitumor activity in prostate liver and various other cancer models supporting its utility for cancer and epigenetics research
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