Medchemexpress LLC Arborinine | 5489-57-6 | 99.9% | 250 MG

Supplier:  Medchemexpress LLC 250MGHY128912

Arborinine is a potent and orally active LSD1 inhibitor, demonstrating significant antitumor activity. It operates by increasing the expression of H3K4me1/2, H3K9me1/2, and E-cad protein, while concurrently decreasing the expression of UBE2O protein levels. Arborinine has been shown to induce cell cycle arrest at the S phase and inhibit cell apoptosis. Its antiproliferative effects have been observed in various cell lines, including 7860, A498, 769P, Caki1, and OSRC2 cells. Furthermore, in in vivo studies, Arborinine exhibited antitumor activity in mouse models by inhibiting tumor growth without affecting body weight.

• Potent LSD1 inhibitor.
• Orally active.
• Modulates gene expression: increases the expression of H3K4me1/2, H3K9me1/2, and E-cad protein.
• Decreases UBE2O protein level.
• Induces cell cycle arrest at the S phase.
• Inhibits apoptosis.
• Antitumor activity.

Catalog No. 50-003-41531