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Cayman Chemical ArnbIa sInsIs AlknIn 10mg
SDP

Supplier:  Cayman Chemical 2505810 MG

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A naphthoquinone with diverse biological activities; enantiomer of shikonin; selectively inhibits tumor-specific PKM2 (IC50 = 0.3 μM) over PKM1 and PKL; inhibits proliferation of HCT116 and SW480 colorectal cancer cells (IC50s = 2.38 and 4.53 μM, respectively); halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells at 3 μM; increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells at 1 μM; active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively); scavenges DPPH radicals in a cell-free assay (EC50 = 22 ppm)

Catalog No. 50-293-3577


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