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Medchemexpress LLC ARS-853 | 1629268-00-3 | 98.39% | 432.94 | 500 MG
Supplier: Medchemexpress LLC HY19706500MG
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein, thereby preventing its activation. This compound is intended for research use only.
- Cell-active and selective KRAS G12C inhibitor.
- Inhibits mutant KRAS-driven signaling.
- Prevents activation of GDP-bound oncoprotein.
- Reduces GTP-bound KRAS levels by more than 95% at 10 μM in KRASG12C-mutant lung cancer cells.
- Inhibits proliferation, effector signaling, and induces apoptosis in KRASG12C mutant cell lines.
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