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Medchemexpress LLC ART812 | 2607138-82-7 | 99.9% | 461.79 | 25 MG
Supplier: Medchemexpress LLC 25MGHY139289
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. It also has an IC50 value of 240 nM for cell-based microhomology-mediated end joining (MMEJ). The compound elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells and shows significant tumor inhibition in rats with MDA-MB-436 BRCA1/SHLD2 defective tumors.
- Orally active DNA polymerase Polθ inhibitor
- IC50 value of 7.6 nM for Polθ
- IC50 value of 240 nM for cell-based microhomology-mediated end joining (MMEJ)
- Elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells
- Shows significant tumor inhibition in rats with MDA-MB-436 BRCA1/SHLD2 defective tumors
- Purity of 99.9%
- Molecular weight of 461.79
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