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Medchemexpress LLC AS 1411 sodium (AGRO-100 sodium) | 99.5% | 8272.31 | 1 MG
Supplier: Medchemexpress LLC HY147081A1MG
AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer that targets nucleoproteins. It inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and serves as a carrier to precisely deliver nanoparticles, oligonucleotides, and small molecules to cancer cells. It reduces PRMT5 expression, inhibiting tumor growth in DU145 prostate cancer cells, and blocks the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells.
- Inhibits tumor cell proliferation.
- Reduces PRMT5 expression.
- Blocks nucleoprotein binding to bcl-2 mRNA.
- Inhibits breast cancer cell proliferation when coupled with Jin nanospheres.
- Crosses the blood-brain barrier with low tissue toxicity.
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