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Apexbio Technology LLC AS-604850 648449-76-7 5mg
Supplier: Apexbio Technology LLC B21815
AS-604850 is a small-molecule inhibitor targeting phosphoinositide 3-kinase gamma (PI3K ) It is designed to inhibit PI3K activity and thereby regulate PI3K -mediated signaling pathways involved in cellular responses AS-604850 exerts its biological activity primarily through selective ATP-competitive inhibition of PI3K In cell-based studies AS-604850 demonstrates inhibitory activity with an IC50 of approximately 2 5 M It exhibits notable selectivity approximately 30-fold over PI3K and PI3K and around 18-fold over PI3K Based on these pharmacological properties AS-604850 holds research potential in studying PI3K -associated biological processes and disease models including chemokine-induced Akt phosphorylation cell migration in macrophages and monocytes apoptosis in hepatocytes and neutrophil infiltration in inflammatory models
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