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Medchemexpress LLC AS-85 | 2323623-80-7 | 98.1% | C26H28F3N5O3S2 | 1 ML
Supplier: Medchemexpress LLC HY14143010MM/1ML
AS-85 is a potent ASH1L histone methyltransferase inhibitor with anti-leukemic activity. It strongly binds to the ASH1L SET domain, inhibiting the growth of various leukemia cells. This compound is stable under recommended storage conditions and is supplied as a ready-for-reconstitution solution.
- Potent ASH1L histone methyltransferase inhibitor (IC50=0.6 μM).
- Exhibits anti-leukemic activity against leukemia cells with MLL1 translocations (GI50 values from 5 μM to 25 μM).
- Strongly binds to the ASH1L SET domain (Kd value of 0.78 μM).
- Supplied as a 10 mM solution in 1 mL DMSO, ready for reconstitution.
- Stable under recommended storage conditions.
- Appears as a light yellow to yellow solid.
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