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Cayman Chemical AS605240 Inhibitors
Supplier: Cayman Chemical 100077075 MG
A potent inhibitor of PI3Kγ; inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner (IC50s = 8, 60, 270, and 300 nM, respectively); inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells (IC50 = 90 nM); suppresses joint inflammation in mouse models of rheumatoid arthritis; reduces RANTES-induced peritoneal neutrophil recruitment in a mouse model of leukocyte chemotaxis (ED50 = 9.1 mg/kg)
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