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Apexbio Technology LLC AS8351 796-42-9 10mg
Supplier: Apexbio Technology LLC B608410
AS8351 (CAS 796-42-9) is a small molecule inhibitor of histone demethylases particularly targeting enzymes containing the JmjC domain that require -ketoglutarate and Fe(II) as cofactors AS8351 has been shown to interfere with epigenetic regulation by competing with -ketoglutarate and chelating Fe(II) thereby modulating histone methylation status In cellular assays removal of AS8351 from fibroblast treatment regimens significantly reduced the induction of beating cardiomyocyte clusters indicating its necessity for chemical reprogramming Further studies implicate KDM5B as a likely target for AS8351-mediated effects in promoting cardiomyocyte generation AS8351 is currently used in preclinical research
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