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Medchemexpress LLC ASP-8731 | 2488255-42-9 | 98.4% | 395.41 | 1 ML
Supplier: Medchemexpress LLC HY16787410MM/1ML
ASP-8731 is an orally active BACH1 inhibitor that activates antioxidant, anti-inflammatory, and globin gene pathways by relieving BACH1's inhibitory effect on NRF2-mediated gene transcription. It upregulates HMOX1, FTH1, and various globins (HGB, HBG, HBA), increasing fetal hemoglobin (HbF) and inducing F-cell production. It also reduces inflammatory responses, white blood cell counts, heme-induced glutathione depletion, and microcirculatory stasis, showing potential for inhibiting sickle cell disease and related hematological disorders.
- Orally active BACH1 inhibitor
- Activates antioxidant, anti-inflammatory, and globin gene pathways
- Increases fetal hemoglobin (HbF) levels
- Reduces inflammation and white blood cell counts
- Blocks heme-induced glutathione depletion and microcirculatory stasis
- Potential for sickle cell disease treatment
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