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Medchemexpress LLC AT-533 | 908112-37-8 | 98.4% | 410.51 | 100 MG
Supplier: Medchemexpress LLC HY148877100MG
AT-533 is a potent Hsp90 and HSV inhibitor. It suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway and inhibits the activation of downstream pathways such as Akt/mTOR/p70S6K, Erk1/2, and FAK. Additionally, it inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).
- Potent Hsp90 and HSV inhibitor
- Suppresses tumor growth
- Inhibits angiogenesis by blocking HIF-1α/VEGF/VEGFR-2 signaling
- Inhibits Akt/mTOR/p70S6K, Erk1/2, and FAK pathways
- Inhibits tube formation, cell migration, and invasion of HUVECs
- Shows anti-angiogenic ability in CAM model
- Decreases TNF-α, IL-1β, and IL-6 production
- No significant toxicity in animal studies
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