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Medchemexpress LLC AT-533 | 908112-37-8 | 98.4% | 410.51 | 50 MG
Supplier: Medchemexpress LLC HY14887750MG
AT-533 is a potent inhibitor of Heat Shock Protein 90 (Hsp90) and Herpes Simplex Virus (HSV). It demonstrates anti-tumor and anti-angiogenic properties by targeting the HIF-1α/VEGF/VEGFR-2 signaling pathway, and suppresses downstream pathways including Akt/mTOR/p70S6K, Erk1/2, and FAK.
- Potent Hsp90 and HSV inhibitor.
- Suppresses tumor growth and angiogenesis.
- Inhibits key signaling pathways: Akt/mTOR/p70S6K, Erk1/2, and FAK.
- Reduces tube formation, cell migration, and invasion in HUVECs.
- Demonstrates anti-angiogenic activity in CAM models.
- Decreases inflammatory markers TNF-α, IL-1β, and IL-6.
- Shows no adverse reactions in subacute toxicology studies.
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