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Apexbio Technology LLC AT13148 1056901-62-2 50mg
Supplier: Apexbio Technology LLC B415850
AT13148 (CAS 1056901-62-2) is an orally bioavailable ATP-competitive inhibitor targeting multiple AGC family kinases including AKT (IC50 38 nM) p70S6 kinase (IC50 8 nM) PKA (IC50 3 nM) SGK (IC50 63 nM) and Rho kinase (IC50 4 nM) In vitro AT13148 suppresses AGC kinase activity and inhibits proliferation in various human cancer cell lines with GI50 values ranging from 1 54 M to 3 77 M In vivo studies demonstrate its antitumor efficacy in human xenograft models such as PTEN-deficient MES-SA uterine sarcoma and HER2-positive PIK3CA-mutant BT474 breast cancer This molecule is valuable for investigating AGC kinase signaling and tumor biology
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