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Cayman Chemical AT2 AgonIst C21 10mg
Supplier: Cayman Chemical 3375810 MG
An AT2 receptor agonist; selectively binds to the AT2 receptor over the AT1 receptor (Kis = 0.4 and >10 µM, respectively); induces neurite outgrowth in NG 108-15 cells at 0.1 µM; reduces mean arterial blood pressure in anaesthetized SHRs at 0.05 mg/kg; reduces right ventricle hypertrophy and fibrosis, as well as lung interstitial and perivascular fibrosis, in an MCT-induced rat model of pulmonary hypertension at 0.3 mg/kg; increases survival and reduces neurological deficits in an MCAO-induced mouse model of cerebral ischemia
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