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Selleck Chemical LLC AT406 (SM-406) 5mg 1071992-99-8 ARRY-334543, Debio1143
Supplier: Selleck Chemical LLC S27545MG
AT406 (SM-406, ARRY-334543, Debio1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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