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Apexbio Technology LLC ATB-346 1226895-20-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B35845.1
ATB-346 (CAS 1226895-20-0) is a hydrogen sulfide-releasing derivative of the nonsteroidal anti-inflammatory drug (NSAID) naproxen It exerts anti-inflammatory effects by inhibiting prostaglandin E2 (PGE2) levels and fully suppressing whole blood thromboxane B2 (TXB2) synthesis In preclinical models ATB-346 significantly reduced paw swelling in rats with adjuvant-induced arthritis when administered on days 14 and 21 Notably it produced minimal gastrointestinal damage relative to naproxen which induced substantial intestinal injury under similar dosing conditions ATB-346 is thus a valuable tool for investigating hydrogen sulfide-mediated anti-inflammatory mechanisms and NSAID-induced gastrointestinal safety
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