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Apexbio Technology LLC Atractyloside Dipotassium Salt 102130-43-8 1mg
Supplier: Apexbio Technology LLC A81881
Atractyloside Dipotassium Salt (CAS 102130-43-8) is a selective inhibitor of mitochondrial ADP/ATP translocase (AAT) disrupting the exchange of ATP and ADP across the mitochondrial inner membrane In cellular models such as Ehrlich ascites tumor cells atractyloside (3 mM) reduced cell proliferation by 70% with mitochondrial ultrastructure alterations observed normal proliferation and macromolecular synthesis recovered upon removal of the inhibitor In rabbit skeletal muscle sarcoplasmic reticulum atractyloside impaired Ca influx through channel inhibition and in rat cardiac mitochondria it dose-dependently suppressed chloride channels This compound is widely used to study mitochondrial function and cellular energy metabolism
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