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Medchemexpress LLC Autophagy inducer 7 | 944159-20-0 | 410.55 | 5 MG
Supplier: Medchemexpress LLC HY1710475MG
Autophagy inducer 7 (Compound SSA) is an Autophagy and Apoptosis inducer. It activates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. It suppresses DNA synthesis and causes a G0-G1 cell-cycle arrest. Autophagy inducer 7 inhibits tumor cell growth.
- Inhibits the growth of human lung adenocarcinoma cell lines
- Induces apoptosis in various cell lines
- Inhibits DNA synthesis and increases cells in G0-G1 phase
- Induces autophagy and increases autophagic flux by inhibiting Akt/mTOR/p70S6k signaling
- Induces dose- and time-dependent cleavage of cytosolic LC3-I to autophagosome-associated LC3-II
- Decreased p62 expression
- Displayed accumulation of vesicle-like structures within the cytoplasm
- Increased both the number and size of acidic vesicles within the cytoplasm
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