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Medchemexpress LLC AZ-5104 | 1421373-98-9 | 99.91% | 200 MG
Supplier: Medchemexpress LLC HYB0793200MG
AZ-5104 is an active, demethylated metabolite of AZD 9291 and functions as an EGFR inhibitor. It demonstrates inhibitory effects on EGFR phosphorylation across various cell lines, targeting both mutant and wild-type EGFR.
- Inhibits EGFR with specific IC50 values across multiple targets
- Effective in tumor shrinkage in C/L858R and C/L+T mice
- Shows minimal off-target activity against non-HER family kinases
- Potentially targets both HER2 and HER4 kinase activity
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 2 years or -20°C for 1 year
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