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Medchemexpress LLC AZ 628 | 878739-06-1 | 99.4% | 451.52 | 10 MG
Supplier: Medchemexpress LLC HY1100410MG
AZ 628 is a pan-Raf kinase inhibitor with IC50s of 105, 34, and 29 nM for B-Raf, B-RafV600E, and c-Raf-1, respectively. It reduces the activities of preactivated B-Raf, B-RafV600E, and c-Raf-1 in in vitro kinase assays.
- Inhibits activation of several tyrosine protein kinases including VEGFR2, DDR2, Lyn, Flt1, and FMS.
- Inhibits anchorage-dependent and -independent growth.
- Causes cell cycle arrest.
- Induces apoptosis in colon and melanoma cell lines harboring the B-RafV600E mutation.
- Suppresses growth in cells expressing K-RASG13D.
- Selectively affects viability in K-RAS mutant cells by suppressing MEK and ERK phosphorylation.
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