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Medchemexpress LLC AZ194 | 2241651-99-8 | 99.8% | C34H31F2N3O3 | 1 ML
Supplier: Medchemexpress LLC HY14516910MM/1ML
AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and an inhibitor of NaV1.7 with an IC50 of 1.2 μM. It works by blocking SUMOylation of CRMP2, which selectively reduces the amount of surface-expressed NaV1.7, exhibiting antinociceptive effects.
- First-in-class orally active inhibitor
- Inhibits CRMP2-Ubc9 interaction
- Inhibits NaV1.7 (IC50 = 1.2 μM)
- Blocks SUMOylation of CRMP2
- Selectively reduces surface-expressed NaV1.7
- Exhibits antinociceptive effects
- Provides pain relief in rat models of neuropathic pain
- Restores mechanical sensitivity
- Does not affect motor performance
- Synergizes with commonly used painkillers
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